Anti-CD62P Antibody [A05-6A1] (Biotin) (A279582)

Anti-CD62P Antibody [A05-6A1] (Biotin)

Mouse monoclonal [A05-6A1] antibody to CD62P (Biotin).

This antibody recognises CD63P, also known as P-Selectin, granule membrane protein 140, LECAM and PADGEM. CD62P is a member of the Selectin family of proteins which are transmembrane Ca2+-dependent lectins that mediate adhesion of leukocytes, platelets and the endothelium during inflammation and immune surveillance (McEver 2015). CD62P is expressed by megakaryocytes and endothelial cells and is stored in membranes of a-granules of platelets and Weibel-Palade bodies of endothelial cells. In humans CD62P can also be secreted as a molecule lacking the transmembrane domain. Increased levels of soluble CD62P in peripheral blood has been documented in a variety of diseases including heart disease, diabetes, hypertension and atrial fibrillation. The biotinylated Mouse anti Human CD62P antibody, clone A05-6A1 (MCA6275B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CD62P antibody, clone A01-2H1 (MCA6274GA) as the capture antibody.

ELISA: 1 µg/ml

Human

HEK293 derived recombinant human full length CD62P (Met1- Ala771).

Mouse

Monoclonal

A05-6A1

IgG2b

Protein G affinity chromatography of tissue culture supernatant.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Mouse anti Human CD62P antibody, clone A05-6A1, recognizes CD63P, also known as P-Selectin, granule membrane protein 140, LECAM and PADGEM. CD62P is a member of the Selectin family of proteins which are transmembrane Ca2+-dependent lectins that mediate adhesion of leukocytes, platelets and the endothelium during inflammation and immune surveillance (McEver 2015). CD62P is expressed by megakaryocytes and endothelial cells and is stored in membranes of a-granules of platelets and Weibel-Palade bodies of endothelial cells. In humans CD62P can also be secreted as a molecule lacking the transmembrane domain. Increased levels of soluble CD62P in peripheral blood has been documented in a variety of diseases including heart disease, diabetes, hypertension and atrial fibrillation (Polgar et al. 2005).The biotinylated Mouse anti Human CD62P antibody, clone A05-6A1 (MCA6275B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CD62P antibody, clone A01-2H1 (MCA6274GA) as the capture antibody.

CD62 antigen-like family member P, GMP-140, GMRP, Granule membrane protein 140, GRMP, LECAM3, Leukocyte-endothelial cell adhesion molecule 3, P-selectin, PADGEM, Platelet activation dependent granule-external membrane protein, SELP

This product is for research use only. It is not intended for diagnostic or therapeutic use.