Recombinant Anti-CD5 Antibody [C5/4561R] (A278090)

Anti-CD5 Antibody [C5/4561R]

Recombinant rabbit monoclonal [C5/4561R] antibody to CD5.

The CD5 antigen is a transmembrane glycoprotein expressed on the surface of practically all mature human T-cells (about 10% of CD4+ T-cells being CD5 negative). In immature (CD34+) T-cells, CD5 is weakly expressed, the intensity of expression increasing with maturation. CD5 is also expressed in a small subset of normal human B-cells (20% of B-cells in the peripheral blood, scattered cells in the lymph node mantle zone). The CD5+ cells are probably involved in B-T interaction and their ligand is CD72 which is expressed on all B cells. It appears that CD5+ B-cells on activation primarily produce IgM. They also produce more autoantibodies than normal CD5 negative B-cells. Thus, the CD5+ B-cell population is expanded in rheumatoid arthritis and systemic lupus erythematosus. The CD5 antibody reacts with CD5 expressed on B and T cells, and may be a useful aid for the classification of B and T-cell malignancies. This includes B-cell chronic lymphoid leukemia (B-CLL), B-cell small lymphocytic lymphoma (B-SLL), mantle cell lymphoma (MCL) and T-cell lymphoma and leukemia.

IHC-P: 1-2 µg/ml

Human

Recombinant full-length human CD5. The immunogen contains the specific extracellular domain of human CD5 (D32-P372).

Rabbit

Monoclonal

C5/4561R

Protein A/G chromatography.

200 µg/ml

67 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-CD5 Antibody [C5/4561R] - BSA and Azide free (A278678).

LEU1, Lymphocyte antigen T1/Leu-1, T-cell surface glycoprotein CD5