This antibody reacts with Ig domain of CD47 protein. CD47, originally named integrin-associated protein (IAP), is a 50kDa protein containing five membrane-spanning sequences and a short cytoplasmic tail. CD47 plays a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It is important in memory formation and synaptic plasticity in the hippocampus. CD47 may play a role in membrane transport and/or integrin dependent signal transduction.
Immunofluorescent analysis of PFA fixed MCF-7 cells stained with Anti-CD47 Antibody [IAP/964] followed by Goat Anti-Mouse IgG (CF® 488) (Green). The nuclear counterstain is RedDot.
SDS-PAGE analysis of Anti-CD47 Antibody [IAP/964] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.
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