Anti-CD40L Antibody [CD40LG/4675] (A277856)

Anti-CD40L Antibody [CD40LG/4675]

Mouse monoclonal [CD40LG/4675] antibody to CD40L.

CD40LG expression is mainly confined to the CD4-positive-T-cell subset. Its expression is induced shortly after T-cell activation and represents an early activation marker of T lymphocytes. CD40 is constitutively expressed mainly on B cells, macrophages, and dendritic cells. The CD40-CD40L pathway has been shown to play multiple functional roles in the healthy immune system. It enhances the antigen-specific T-cell response through the activation of dendritic cells and the induction of interleukin-12 production. For example, engagement of CD40 on endothelial cells by activated T cells expressing CD40L leads to upregulation of adhesion molecules such as ICAM-1, VCAM-1, and E-selectin. Activation of APC by CD40-CD40L interaction induces the production of inflammatory cytokines, chemokines, NO, and metalloproteinases. Interaction of CD4-positiveCD40LG-positiveT cells with CD40 on B cells leads to B-cell differentiation, proliferation, immunoglobulin (Ig) isotype switching, and formation of memory B cells.

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 108-261, of human CD40L protein. The exact sequence is proprietary.

Mouse

Monoclonal

CD40LG/4675

IgG1

Protein A/G chromatography.

200 µg/ml

36 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-CD40L Antibody [CD40LG/4675] - BSA and Azide free (A278444).

CD154, CD40 ligand, CD40-L, CD40LG, T-cell antigen Gp39, TNF-related activation protein, TRAP, Tumor necrosis factor ligand superfamily member 5