Anti-CD40 Antibody [CD40/4940] (A314704)

Anti-CD40 Antibody [CD40/4940]

Mouse monoclonal [CD40/4940] antibody to CD40.

CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is expressed on B-lymphocytes, follicular dendritic cells, bone marrow-derived dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zones of secondary lymphoid organs.

ELISA, IHC-P

U2OS or L-428 cells. Human tonsil, spleen or thymus.

IHC: 1-2 µg/ml

Human

Recombinant fragment of human CD40 protein (around Amino Acids 1-200). The exact sequence is proprietary.

Mouse

Monoclonal

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

43 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.