Anti-CD31 Antibody [C31.3 + JC/70A] (A277741)

Anti-CD31 Antibody [C31.3 + JC/70A]

Mouse monoclonal [C31.3 + JC/70A] antibody to CD31.

CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of adhesion molecules. CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells. Staining of nonvascular tumors (excluding hematopoietic neoplasms) is rare. CD31 MAb reacts with normal, benign, and malignant endothelial cells which make up blood vessel lining. The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially a predictor of tumor recurrence.

WB, IHC-P

WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human, Cynomolgus Monkey, Rabbit

Clone C31.3: Recombinant full-length human CD31 protein. Clone JC/70A: Membrane preparation of a spleen from a patient with hairy cell leukemia.

Mouse

Oligoclonal

C31.3 + JC/70A

IgG1, kappa + IgG1, kappa

Protein A/G chromatography.

200 µg/ml

~100 kDa (endothelium) / ~130 kDa (platelets)

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

EndoCAM, GPIIA', PECA1, PECAM-1, PECAM1, Platelet endothelial cell adhesion molecule