Anti-CD28 Antibody [204.12] (A250632)

Anti-CD28 Antibody [204.12]

Mouse monoclonal [204.12] antibody to CD28.

This antibody recognizes a glycoprotein of 44-88kDa, which is identified as CD28. It is the critical T-cell co-stimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its co-stimulation role, CD28 functions in preventing T-cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.

Flow Cytometry, IF

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml

Human, Porcine, Bovine, Sheep, Mouse

Stimulated human leucocytes.

Mouse

Monoclonal

204.12

IgG2a

kappa

Protein A/G chromatography.

200 µg/ml

44 kDa (monomer) / 88 kDa (dimer)

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-CD28 Antibody [204.12] - BSA and Azide free (A253812).

T-cell-specific surface glycoprotein CD28, TP44