Recombinant Anti-CD23 Antibody [FCER2/8234R] (A314628)

Anti-CD23 Antibody [FCER2/8234R]

Recombinant rabbit monoclonal [FCER2/8234R] antibody to CD23.

CD23 (FCE2) is a type II integral membrane glycoprotein that is expressed on mature B cells, monocytes, eosinophils, platelets and dendritic cells. CD23 is a low affinity IgE receptor that mediates IgE-dependent cytotoxicity and phagocytosis by macrophages and eosinophils. CD23 associates as an oligomer where cooperative binding of at least two lectin domains is required for high affinity IgE binding to CD23. It may play a role in antigen presentation by B cells by interacting with CD40. CD23 has been shown to be associated with the Fyn tyrosine kinase. The truncated molecule can be secreted, then function as a potent mitogenic growth factor. CD23 is expressed on a subpopulation of peripheral blood cells, B-lymphocytes and on EBV transformed B lymphoblastoid cell lines. CD23 is also detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some cases on centroblastic/centrocytic lymphoma.

Human lymph node or tonsil (IHC).

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 200-300) of human FCER2/CD23 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

FCER2/8234R

kappa

Protein A/G chromatography.

200 µg/ml

37 kDa (soluble form) / 45 kDa (membrane-bound form)

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

BLAST-2, C-type lectin domain family 4 member J, CD23A, CLEC4J, Fc-epsilon-RII, FCE2, FCER2, IGEBF, Immunoglobulin E-binding factor, Low affinity immunoglobulin epsilon Fc receptor, Lymphocyte IgE receptor