Anti-CD23 Antibody [FCER2/6888] (A314626)

$765

Mouse monoclonal [FCER2/6888] antibody to CD23 for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 4-6 business days.
Name
Anti-CD23 Antibody [FCER2/6888]
Description
Mouse monoclonal [FCER2/6888] antibody to CD23.
Specificity
CD23 (FCE2) is a type II integral membrane glycoprotein that is expressed on mature B cells, monocytes, eosinophils, platelets and dendritic cells. CD23 is a low affinity IgE receptor that mediates IgE-dependent cytotoxicity and phagocytosis by macrophages and eosinophils. CD23 associates as an oligomer where cooperative binding of at least two lectin domains is required for high affinity IgE binding to CD23. It may play a role in antigen presentation by B cells by interacting with CD40. CD23 has been shown to be associated with the Fyn tyrosine kinase. The truncated molecule can be secreted, then function as a potent mitogenic growth factor. CD23 is expressed on a subpopulation of peripheral blood cells, B-lymphocytes and on EBV transformed B lymphoblastoid cell lines. CD23 is also detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some cases on centroblastic/centrocytic lymphoma.
Applications
IHC-P
Positive Control
Human lymph node or tonsil (IHC).
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment (around Amino Acids 48-321) of human FCER2/CD23 protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
FCER2/6888
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
37 kDa (soluble form) / 45 kDa (membrane-bound form)
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
BLAST-2, C-type lectin domain family 4 member J, CD23A, CLEC4J, Fc-epsilon-RII, FCE2, FCER2, IGEBF, Immunoglobulin E-binding factor, Low affinity immunoglobulin epsilon Fc receptor, Lymphocyte IgE receptor
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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