Recombinant Anti-CD20 Antibody [rIGEL/773] (A250599)

Anti-CD20 Antibody [rIGEL/773]

Recombinant mouse monoclonal [rIGEL/773] antibody to CD20.

This antibody recognizes a protein of 30-33kDa, which is identified as CD20. It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre-B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. This MAb can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood and B cell localization in tissues. It reacts with the majority of B-cells present in peripheral blood and lymphoid tissues and their derived lymphomas. In lymphoid tissue, germinal center blasts and B-immunoblasts are particularly reactive. It is a reliable antibody for ascribing a B-cell phenotype in known lymphoid tissues. Rarely, CD20-positive T-cell lymphomas have been reported. Reactivity has also been noted with Reed-Sternberg cells in cases of Hodgkin s disease, particularly of lymphocyte predominant type.

IF, Flow Cytometry, IHC-P

IF: 1-2 µg/ml, Flow Cytometry: 1-2 µg/million cells, IHC-P: 1-2 µg/ml

Human

Recombinant full-length human MS4A1 protein.

Mouse

Monoclonal

rIGEL/773

IgG1

Protein A/G chromatography.

200 µg/ml

33-37 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-CD20 Antibody [rIGEL/773] - BSA and Azide free (A253779).