Anti-CD163 Antibody [M130/2162] (A250604)

Anti-CD163 Antibody [M130/2162]

Mouse monoclonal [M130/2162] antibody to CD163.

This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

ELISA, IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 43-196, of human CD163 protein. The exact sequence is proprietary.

Mouse

Monoclonal

M130/2162

IgG2b

Protein A/G chromatography.

200 µg/ml

140 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-CD163 Antibody [M130/2162] - BSA and Azide free (A253784).

Hemoglobin scavenger receptor, M130, Scavenger receptor cysteine-rich type 1 protein M130