Anti-CD146 Antibody [MCAM/1101] (A249290)

Anti-CD146 Antibody [MCAM/1101]

Mouse monoclonal [MCAM/1101] antibody to CD146.

The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

Flow Cytometry, IF, IHC-P

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human

Recombinant human MCAM protein.

Mouse

Monoclonal

MCAM/1101

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

130 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-CD146 Antibody [MCAM/1101] - BSA and Azide free (A252470).

Cell surface glycoprotein MUC18, Cell surface glycoprotein P1H12, MCAM, Melanoma cell adhesion molecule, Melanoma-associated antigen A32, Melanoma-associated antigen MUC18, MUC18, S-endo 1 endothelial-associated antigen