Anti-CD13 Antibody [WM15] (A248759)

Anti-CD13 Antibody [WM15]

Mouse monoclonal [WM15] antibody to CD13.

This antibody recognizes an integral membrane glycoprotein of 150kDa, identified as CD13 (also known as aminopeptidase-N). The antibody This antibody recognizes an extracellular epitope. The CD13 antigen is present on most cells of myeloid origin including granulocytes, monocytes, mast cells, and GM-progenitor cells. It is also expressed by the majority of AML, CML in myeloid blast crisis, and in a smaller fraction of lymphoid leukemias. CD13 is absent from normal lymphocytes, platelets and erythrocytes. CD13 is also present on fibroblasts; endothelial cells, epithelial cells from renal proximal tubules and intestinal brush border, bone marrow stromal cells, osteoclasts, and cells lining bile duct canaliculi. CD13 is identical to aminopeptidase N (APN), a prominent membrane-bound metalloprotease present on the surface of intestinal brush border and renal tubules. CD13 plays a role in metabolism of biologically active peptides, in phagocytosis, and in bactericidal/tumoricidal activities. It also serves as a receptor for human coronaviruses (HCV). The lineage-restricted pattern of expression of CD13 within the hemopoietic compartment suggests that it may be important in myeloid cell differentiation.

Flow Cytometry, IF, IHC-Fr

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IHC-Fr: 1-2 µg/ml

Human

Human AML cells.

Mouse

Monoclonal

WM15

IgG1

Protein A/G chromatography.

200 µg/ml

150 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-CD13 Antibody [WM15] - BSA and Azide free (A251939).

Alanyl aminopeptidase, Aminopeptidase M, Aminopeptidase N, ANPEP, AP-M, AP-N, APN, CD103, gp150, hAPN, HML-1 antigen, Integrin alpha-E, Integrin alpha-IEL, ITGAE, Microsomal aminopeptidase, Mucosal lymphocyte 1 antigen, Myeloid plasma membrane glycoprotein CD13, PEPN