Anti-CD11c Antibody [CBR-p150/4G1] - BSA and Azide free (A279993)

Anti-CD11c Antibody [CBR-p150/4G1] - BSA and Azide free

Mouse monoclonal [CBR-p150/4G1] antibody to CD11c.

This antibody recognises human CD11c, otherwise known as integrin alpha X chain and leukocyte adhesion receptor p150,95, a ~150 kDa type I transmembrane protein and member of the integrin alpha chain family, expressed by monocytes, macrophages, granulocytes and NK cells, and is a marker for hairy cell leukaemia cells. CD11c combines with the CD18 beta chain (ITGB2) to form the leukocyte specific integrin CR4, acts as a mediator of leukocyte adherence to endothelium, and binds to the ligands CD54 (ICAM1), iC3b and fibrinogen. Mouse anti Human CD11c antibody, clone CBR-p150/4G1 inhibits the binding of CD11c to endothelial cells. Mouse anti Human CD11c antibody, clone CBR-p150/4G1 does not recognize CD11a, CD11b or CD18.

Flow Cytometry, IHC-Fr, Functional Assays

IHC-Fr: 5 - 10 µg/ml, Use 10µl of the suggested working dilution to label 1x10⁶ cells in 100µl.

Human

Recombinant human CD11c.

Mouse

Monoclonal

CBR-p150/4G1

IgG2a

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline.

Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Mouse anti Human CD11c antibody, clone CBR-p150/4G1 specifically recognizes human CD11c, otherwise known as integrin alpha X chain and leukocyte adhesion receptor p150,95, a ~150 kDa type I transmembrane protein and member of the integrin alpha chain family, expressed by monocytes, macrophages, granulocytes and NK cells, and is a marker for hairy cell leukaemia cells. CD11c combines with the CD18 beta chain (ITGB2) to form the leukocyte specific integrin CR4, acts as a mediator of leukocyte adherence to endothelium, and binds to the ligands CD54 (ICAM1), iC3b and fibrinogen. Mouse anti Human CD11c antibody, clone CBR-p150/4G1 inhibits the binding of CD11c to endothelial cells. Mouse anti Human CD11c antibody, clone CBR-p150/4G1 does not recognize CD11a, CD11b or CD18.

CD11 antigen-like family member C, Integrin alpha-X, ITGAX, Leu M5, Leukocyte adhesion glycoprotein p150,95 alpha chain, Leukocyte adhesion receptor p150,95