Anti-CD11a Antibody [MEM-83] - Low endotoxin, Azide free (A86133)

Anti-CD11a Antibody [MEM-83] - Low endotoxin, Azide free

Mouse monoclonal [MEM-83] antibody to CD11a.

This antibody reacts with CD11a (alpha subunit of human LFA-1), a 170-180 kDa type I transmembrane glycoprotein expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils.

Functional Studies, Flow Cytometry, IP

FUNC: This antibody directly induces the binding of T cells to purified ICAM-1. Using an in vitro-translated CDlla cDNA deletion series, the MEM-83 activation epitope was mapped to the "I" domain of the LFA-1 alpha subunit. The studies have therefore identified a novel LFA-1 activation epitope mapping to the I domain of LFA-1, which could play a role in the regulation of LFA-1 binding to ICAM-1, Flow Cytometry: 1 µg/ml.

Human

Human peripheral blood lymphocytes.

Mouse

Monoclonal

MEM-83

IgG1

Protein A chromatography.

1 mg/ml

170-180 kDa

Liquid

Supplied in Phosphate Buffered Saline, pH 7.4, without Sodium Azide (0.2 µm filter sterilized). Endotoxin level is less than 0.01 EU/µg of the protein.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze/thaw cycles.

CD11 antigen-like family member A, Integrin alpha-L, ITGAL, Leukocyte adhesion glycoprotein LFA-1 alpha chain, Leukocyte function-associated molecule 1 alpha chain, LFA-1A