Anti-C-Reactive Protein Antibody [cCRP3] (A280079)

Anti-C-Reactive Protein Antibody [cCRP3]

Mouse monoclonal [cCRP3] antibody to C-Reactive Protein.

This antibody recognises canine C-reactive protein (CRP), a calcium-binding acute phase reactant belonging to the pentraxin family which is secreted into the plasma by the liver in response to cytokine stimulation.CRP belongs to an evolutionally conserved group of pentamer proteins whose function is the protection of an organism against harmful antigens, including invasive infectious agents from bacteria and viruses, and from pyometra and sepsis.Canine CRP is similar in structure to human CRP, however canine CRP differs in that two of the five subunits that make up CRP in dogs are glycosylated while normally none of the subunits making up human CRP are. As clone cCRP3 is specifically raised against dog, this antibody has an advantage over other antibodies raised against human that show cross reactivity with dog, as these cross reactive antibodies may not recognize the glycosylated subunits.Clone cCRP3 recognises a linear epitope.

ELISA, WB

This product is suitable for use in direct and indirect ELISA applications.

Canine

This antibody does not cross react with Human, Cat, Horse, or Rabbit

Canine C-reactive protein (whole molecule).

Mouse

Monoclonal

cCRP3

IgG2b

Protein A affinity chromatography of ascites.

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Store undiluted at 4°C. Do not freeze!

Mouse anti Dog C-reactive protein, clone cCRP3, specifically recognizes canine C-reactive protein (CRP), a calcium-binding acute phase reactant belonging to the pentraxin family which is secreted into the plasma by the liver in response to cytokine stimulation.CRP belongs to an evolutionally conserved group of pentamer proteins whose function is the protection of an organism against harmful antigens, including invasive infectious agents from bacteria and viruses, and from pyometra and sepsis.Canine CRP is similar in structure to human CRP, however canine CRP differs in that two of the five subunits that make up CRP in dogs are glycosylated while normally none of the subunits making up human CRP are. As clone cCRP3 is specifically raised against dog, this antibody has an advantage over other antibodies raised against human that show cross reactivity with dog, as these cross reactive antibodies may not recognize the glycosylated subunits.Clone cCRP3 recognizes a linear epitope.

CRP, PTX1