Recombinant Anti-c-Kit Antibody [C117/8399R] (A314789)

Anti-c-Kit Antibody [C117/8399R]

Recombinant rabbit monoclonal [C117/8399R] antibody to c-Kit.

This MAb recognizes a protein of 145kDa, identified as CD117/p145kit. It is found on a wide variety of tumor cells including follicular and papillary carcinoma of thyroid, adenocarcinomas from endometrium, lung, ovary, pancreas, and breast as well as malignant melanoma, endodermal sinus tumor, and small cell carcinoma. However, anti-CD117 has been particularly useful in differentiating gastrointestinal stromal tumors from Kaposi s sarcoma, tumors of smooth muscle origin, fibromatosis, and neural tumors of the GI tract. Anti-CD117 is also useful in recognizing myeloblasts in bone marrow biopsy and clot section.

Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis and mast cells in the dermis of normal skin.

ELISA: 2-4 µg/ml for coating, IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 50-250) of human KIT protein. The exact sequence is proprietary.

Rabbit

Monoclonal

C117/8399R

kappa

Protein A/G chromatography.

200 µg/ml

~145 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

CD117, KIT, Mast/stem cell growth factor receptor Kit, p145 c-kit, PBT, Piebald trait protein, Proto-oncogene c-Kit, SCFR, Tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog