Anti-c-Jun Antibody (A283420)

$435

Rabbit polyclonal antibody to c-Jun for WB.

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 4-6 business days.
Name
Anti-c-Jun Antibody
Description
Rabbit polyclonal antibody to c-Jun.
Specificity
This antibody recognises c-Jun, also known as p39. The c-Jun transcription factor is encoded by the c-Jun oncogene and dimerizes with c-Fos, JDP and ATF family members to form the AP-1 transcription factor. AP-1 is activated by a variety of stimuli including cytokines, stress and growth factors, and plays a critical role in cellular processes ranging from proliferation to apoptosis. c-Jun becomes phosphorylated on Serine 63 and Serine 73 by MAPK8 (SAPK/JNK) and PLK3, which regulate c-Jun transcription. c-Jun has been implicated in early tumor development, invasion and metastasis, and due to these findings has been identified as a target for cancer therapies.
Applications
WB
Dilutions
WB: 1:400
Reactivity
Mouse, Human, Rat
Immunogen
A peptide corresponding to the N-terminus of mouse c-Jun.
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Conjugate

Unconjugated

Purification
Affinity chromatography.
Concentration
200 µg/ml
Molecular Weight
Approximately 36 kDa when run under reducing conditions
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.2% Gelatin and 0.1% Sodium Azide.
Storage
Store undiluted at 4°C. Do not freeze! Should this product contain a precipitate we recommend microcentrifugation before use.
General Notes
Rabbit anti c-Jun antibody recognizes c-Jun, also known as p39. The c-Jun transcription factor is encoded by the c-Jun oncogene and dimerizes with c-Fos, JDP and ATF family members to form the AP-1 transcription factor (Eferl and Wagner 2003). AP-1 is activated by a variety of stimuli including cytokines, stress and growth factors, and plays a critical role in cellular processes ranging from proliferation to apoptosis. c-Jun becomes phosphorylated on Serine 63 and Serine 73 by MAPK8 (SAPK/JNK) and PLK3, which regulate c-Jun transcription. c-Jun has been implicated in early tumor development, invasion and metastasis, and due to these findings has been identified as a target for cancer therapies.
Synonyms
Activator protein 1, AP1, JUN, p39, Proto-oncogene c-Jun, Transcription factor AP-1 subunit Jun, Transcription factor Jun, V-jun avian sarcoma virus 17 oncogene homolog
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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