Anti-BRCA1 (phospho Ser1423) Antibody (A283562)

Anti-BRCA1 (phospho Ser1423) Antibody

Rabbit polyclonal antibody to BRCA1 (phospho Ser1423).

This antibody recognises breast cancer type 1 susceptibility protein encoded by BRCA1, also known as RING finger protein 53, when phosphorylated at serine 1423. Breast cancer susceptibility genes BRCA1 and BRCA2 are associated with hereditary breast and ovarian cancers. BRCA1 is a tumor suppressor gene encoding an E3 ubiquitin protein ligase that plays a major role in DNA damage repair. BRCA1 is also involved in the regulation of multiple processes including transcription and cell cycle progression. BRCA1 is reported to be phosphorylated by ATM and ATR at serine 1423 in response to DNA damage.

WB: 1:500 - 1:2,000

Human

Phospho-specific peptide corresponding to residues surrounding Ser1423 of human BRCA1.

Rabbit

Polyclonal

IgG

Liquid

Supplied in Phosphate Buffered Saline with 50% Glycerol and 0.02% Sodium Azide.

Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti BRCA1 (pSer1423) antibody recognizes breast cancer type 1 susceptibility protein encoded by BRCA1, also known as RING finger protein 53, when phosphorylated at serine 1423. Breast cancer susceptibility genes BRCA1 and BRCA2 are associated with hereditary breast and ovarian cancers. BRCA1 is a tumor suppressor gene encoding an E3 ubiquitin protein ligase that plays a major role in DNA damage repair (Roy et al. 2011).BRCA1 is also involved in the regulation of multiple processes including transcription and cell cycle progression. BRCA1 is reported to be phosphorylated by ATM and ATR at serine 1423 in response to DNA damage (Tibbetts et al. 2000).

Breast cancer type 1 susceptibility protein, RING finger protein 53, RING-type E3 ubiquitin transferase BRCA1, RNF53