Anti-Bim Antibody (A283966)

Anti-Bim Antibody

Rabbit polyclonal antibody to Bim.

This antibody recognises human Bcl-2 interacting mediator of cell death (Bim), also known as Bod.Bim is a pro-apoptotic protein within the Bcl-2 family, which functions within the intrinsic apotosis pathway. Bim is known to interact with pro-survival proteins including Bcl-2, Bcl-XL and Bcl-w.Bim is expressed in a variety of cell types, where it is maintained in an inactive conformation by phosphorylation or through binding to the microtubule-associated dynein motor complex. Upon certain apoptotic stimuli, Bim is released from microtubules and mediates caspase-dependent apoptosis.

WB, IHC-P

WB: 1:1,000

Human, Mouse, Rat

Synthetic peptide corresponding to amino acids 22-40 of human Bim.

AERPPQLRPGAPTSLQTEP

Rabbit

Polyclonal

IgG

Approximately 22 kDa in K562 and A549 whole cell lysates.

Liquid

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human Bim antibody recognizes human Bcl-2 interacting mediator of cell death (Bim), also known as Bod.Bim is a pro-apoptotic protein within the Bcl-2 family, which functions within the intrinsic apotosis pathway. Bim is known to interact with pro-survival proteins including Bcl-2, Bcl-XL and Bcl-w.Bim is expressed in a variety of cell types, where it is maintained in an inactive conformation by phosphorylation or through binding to the microtubule-associated dynein motor complex. Upon certain apoptotic stimuli, Bim is released from microtubules and mediates caspase-dependent apoptosis.

Bcl-2-like protein 11, Bcl2-interacting mediator of cell death, Bcl2-L-11, BCL2L11