Anti-beta 2 Microglobulin Antibody [BBM.1] (A249750)

Anti-beta 2 Microglobulin Antibody [BBM.1]

Mouse monoclonal [BBM.1] antibody to beta 2 Microglobulin.

This antibody recognizes a protein of 12kDa, identified as microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.

Flow Cytometry, WB, IF, IHC-Fr

Flow Cytometry: 1-2 µg/million cells, WB: 1-2 µg/ml, IF: 1-4 µg/ml, IHC-Fr: 1-2 µg/ml

Human, Non-Human Primates

MOLT-4 human T cell line.

Mouse

Monoclonal

BBM.1

IgG2b

Protein A/G chromatography.

200 µg/ml

12 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-beta 2 Microglobulin Antibody [BBM.1] - BSA and Azide free (A252930).

B2M, Beta-2-microglobulin