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Anti-Bcl-XL (phospho Ser62) Antibody (A283560)

$435

Rabbit polyclonal antibody to Bcl-XL (phospho Ser62) for WB.

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 5-7 business days.
Name
Anti-Bcl-XL (phospho Ser62) Antibody
Description
Rabbit polyclonal antibody to Bcl-XL (phospho Ser62).
Specificity
This antibody recognises bcl-xL, also known as Bcl-2-like protein 1 (Bcl-2-L-1) and apoptosis regulator Bcl-X, when phosphorylated at serine 62. Bcl-xL is a Bcl-2 family member that has an anti-apoptotic function in the apoptosis signaling cascade.Bcl-xL inhibits apoptosis by preventing the release of mitochondrial cytochrome c and the subsequent activation of caspases 3 and 9.Mitotic arrest induces complete phosphorylation of Bcl-xL at serine 62 by cyclin dependent kinase 1 (CDK1), inactivating the anti-apoptotic function of Bcl-xL.
Applications
WB
Dilutions
WB: 1:500 - 1:2,000
Reactivity
Human, Mouse, Rat
Immunogen
Phospho-specific peptide corresponding to residues surrounding Ser62 of human Bcl-xL.
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Conjugate

Unconjugated

Concentration
Lot Specific
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 50% Glycerol and 0.02% Sodium Azide.
Storage
Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.
General Notes
Rabbit anti Bcl-xL (pSer62) antibody recognizes Bcl-xL, also known as Bcl-2-like protein 1 (Bcl-2-L-1) and apoptosis regulator Bcl-X, when phosphorylated at serine 62. Bcl-xL is a Bcl-2 family member that has an anti-apoptotic function in the apoptosis signaling cascade.Bcl-xL inhibits apoptosis by preventing the release of mitochondrial cytochrome c and the subsequent activation of caspases 3 and 9.Mitotic arrest induces complete phosphorylation of Bcl-xL at serine 62 by cyclin dependent kinase 1 (CDK1), inactivating the anti-apoptotic function of Bcl-xL (Terrano et al. 2010).
Synonyms
Apoptosis regulator Bcl-X, Bcl-2-like protein 1, Bcl2-L-1, BCL2L, BCL2L1, BCLX
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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