Anti-Bcl-XL Antibody (A283193)

Anti-Bcl-XL Antibody

Rabbit polyclonal antibody to Bcl-XL.

This antibody recognises the long isoform of human Bcl-2-like protein 1, otherwise known as Bcl-xL, located on the mitochondrial membrane. The Bcl-xL isoform (the longer isoform) is a potent inhibitor of apoptosis. It appears to regulate cell death by binding to and blocking the voltage-dependent anion channel, thereby preventing the release of the caspase activator cytochrome c. High expression of Bcl-xL in tumours correlates to advanced disease and a poor prognosis.

WB: 1 - 2 µg/ml

Human

A peptide corresponding to 14 amino acids near the C-terminus of human Bcl-xL precursor.

Rabbit

Polyclonal

IgG

Approximately 27 kDa in A549 cell lysate

Liquid

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human Bcl-xL antibody recognizes the long isoform of human Bcl-2-like protein 1, otherwise known as Bcl-xL, located on the mitochondrial membrane. The Bcl-xL isoform (the longer isoform) is a potent inhibitor of apoptosis. It appears to regulate cell death by binding to and blocking the voltage-dependent anion channel, thereby preventing the release of the caspase activator cytochrome c. High expression of Bcl-xL in tumours correlates to advanced disease and a poor prognosis.

Apoptosis regulator Bcl-X, Bcl-2-like protein 1, Bcl2-L-1, BCL2L, BCL2L1, BCLX