Recombinant Anti-Aurora B Antibody [rAURKB/1592] - BSA and Azide free (A253706)

Anti-Aurora B Antibody [rAURKB/1592] - BSA and Azide free

Recombinant mouse monoclonal [rAURKB/1592] antibody to Aurora B.

This antibody recognizes a protein of 39kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 89-251, of human Aurora B protein. The exact sequence is proprietary.

Mouse

Monoclonal

rAURKB/1592

IgG1

kappa

Protein A/G chromatography.

1 mg/ml

39 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-Aurora B Antibody [rAURKB/1592] (A250526).

AIK2, AIM-1, AIM1, AIRK2, ARK-2, ARK2, AURKB, Aurora 1, Aurora kinase B, Aurora- and IPL1-like midbody-associated protein 1, Aurora-related kinase 2, Aurora/IPL1-related kinase 2, Serine/threonine-protein kinase 12, STK-1, STK1, STK12, STK5