Anti-Aquaporin 4 Antibody [AQP4/3324] (A277678)

Anti-Aquaporin 4 Antibody [AQP4/3324]

Mouse monoclonal [AQP4/3324] antibody to Aquaporin 4.

In skeletal muscle, AQP4 (aquaporin 4 also known as mercurial insensitive water channel), localizes to the sarcolemma of fast-twitch muscle fibers. Aquaporins (AQPs) are a large family of integral membrane water transport channel proteins that facilitate the transport of water through the cell membrane. This function is conserved in animals, plants and bacteria. Many isoforms of aquaporin have been identified in mammals, designated AQP0through AQP10. Aquaporins are widely distributed and it is not uncommon for more than one type of AQP to be present in the same cell. Although most aquaporins are only permeable to water, AQP3, AQP7, AQP9 and one of the two AQP10 transcripts are also permeable to urea and glycerol. AQP2 is the only water channel that is activated by vasopressin to enhance water reabsorption in the kidney collecting duct. Aquaporins are involved in renal water absorption, generation of pulmonary secretions, lacrimation and the secretion and reabsorption of cerebrospinal fluid and aqueous humor.

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 254-323, of human Aquaporin 4. The exact sequence is proprietary.

Mouse

Monoclonal

AQP4/3324

IgG1

Protein A/G chromatography.

200 µg/ml

34 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Aquaporin 4 Antibody [AQP4/3324] - BSA and Azide free (A278266).

AQP-4, AQP4, Aquaporin-4, Mercurial-insensitive water channel, MIWC, WCH4