Anti-ALDH1L1 Antibody [ALDH1L1/7958] (A314439)

Anti-ALDH1L1 Antibody [ALDH1L1/7958]

Mouse monoclonal [ALDH1L1/7958] antibody to ALDH1L1.

Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde, lipid peroxidation and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH1L1 (aldehyde dehydrogenase 1 family member L1), also known as FTHFD or 10-FTHFD (10-formyltetrahydrofolate dehydrogenase), is a cytosolic protein that is developmentally regulated in the cerebellum. ALDH1L1 binds to folate and catalyzes the conversion of 10-formyltetrahydrofolate (10-FTHF) to tetrahydrofolate (THF). This suggests a possible role for ALDH1L1 in the regulation of cellular THF levels as well as in the inhibition of cell proliferation (as 10-FTHF is essential for the synthesis of purine). In addition, the overexpression of ALDH1L1 can restrict cell proliferation in vitro.

Human kidney or liver.

IHC: 1-2 µg/ml

Human

Recombinant fragment of human ALDH1L1 protein. The exact sequence is proprietary.

Mouse

Monoclonal

ALDH1L1/7958

kappa

Protein A/G chromatography.

200 µg/ml

99 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

10-FTHFDH, Aldehyde dehydrogenase family 1 member L1, Cytosolic 10-formyltetrahydrofolate dehydrogenase, FDH, FTHFD