General Notes
Mouse anti Human adiponectin antibody, cloneD02-7B10, recognizes adiponectin, also known as ACRP30, apM-1, ADIPOQ. Adiponectin is a fat-derived hormone which suppresses glucose production in the liver and enhances fatty acid oxidation in skeletal muscle, and acts as a messenger to allow communication between adipose tissue and other organs (Wang and Scherer, 2016). Adiponectin can elicit several downstream signaling events, including the insulin signaling pathway. Anti-diabetic, anti-inflammatory, and anti-atherogenic effects of adiponectin have been identified, and the protein sensitizes cells to insulin. Decreased adiponecin levels may play a role in development of type 2 diabetes, and therefore, adiponectin has been suggested as a potential therapeutic target for diabetes (Achari and Jain 2017). The biotinylated Mouse anti Human adiponectin antibody, clone D02-7B10 (MCA6175B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human adiponectin antibody, clone D05-9C7 (MCA6174GA) as the capture antibody.