Recombinant Anti-ACTH Antibody [CLIP/7197R] (A314433)

Anti-ACTH Antibody [CLIP/7197R]

Recombinant rabbit monoclonal [CLIP/7197R] antibody to ACTH.

ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH); does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).

Normal pituitary gland or pituitary tumor.

IHC: 1-2 µg/ml

Human

N-terminal fragment of human ACTH conjugated to KLH.

Rabbit

Monoclonal

CLIP/7197R

kappa

Protein A/G chromatography.

200 µg/ml

ACTH is ~5 kDa, POMC precursor: ~30 kDa. The molecular weight of POMC depends upon isoform variation / post-translational modifications.

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Corticotropin-lipotropin, Pro-opiomelanocortin