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Anti-PD-L1 Aptamer [N5] (Biotin) (A321196)

1 Citation
Secondary Structure - Anti-PD-L1 Aptamer [N5] (Biotin) (A321196) - Antibodies.com
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Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 30-45 business days.

  • Specifications

Name
Anti-PD-L1 Aptamer [N5] (Biotin)
Description
Synthetic DNA aptamer to PD-L1 [N5] (Biotin).
Aptamer ID
N5
Conjugate

Biotin

Aptamer Resuspension
Resuspend to 100µM with 10mM Tris-HCl, pH 7.5, and 0.1mM EDTA.
Apatmer Binding Conditions
pH 7.4, with 136mM Sodium Chloride, 2.6mM Potassium Chloride, 4mM Disodium Phosphate, 1.8mM Potassium Phosphate, and 2mM Magnesium Chloride. Binding Temperature: 37°C.
Sequence
5’-dGpdApdTpdTpdGpdApdGpdTpdApdGpdApdTpdApdGpdTpdGpdGpdTpdTpdCpdTpdGpdTpdApdCpdGpdTpdApdGpdTpdGpdApdApdApdGpdApdGpdTpdGpdGp-3’
Aptamer Length
40 nt
Aptamer Molecular Weight (Da)
12,550.2 Da
Aptamer Affinity
Affinity (Kd) = 441 nM
Extinction Coefficient
414300 M-1cm-1
Purification
HPLC
Product Form
Lyophilized
Concentration
Reconstitution dependent.
Formulation
Lyophilized from nuclease-free water (no residual salts).
Storage
Shipped at 4°C. Lyophilized: Store at -20°C. Reconstituted: Store short term at 4°C (i.e. use within days) or aliquot and store at -20°C (medium term: i.e. use within weeks) or -80°C long term. Avoid freeze/thaw cycles.
Product Notes
Anti-PD-L1 Aptamer [N5] (Biotin) (A321196) is a replica of the aptamer described in PMID: 33155587.
General Notes
Aptamers have not been validated by Antibodies.com and they need to be tested/evaluated under identical conditions to which they were reported in the literature including, but not limited to, temperature and matrix/buffer conditions. All aptamers are manufactured on request and have a lead time of 30-45 business days.
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.

  • Scientific Validation DataValidation Data (1)

Secondary Structure - Anti-PD-L1 Aptamer [N5] (Biotin) (A321196) - Antibodies.comEnlarge Image

Anti-PD-L1 Aptamer [N5] (Biotin) (A321196)

Secondary structure of Anti-PD-L1 Aptamer [N5] (Biotin) (A321196).

  • Product Citations (1)

PubMed LogoView Publication
Selection of threose nucleic acid aptamers to block PD-1/PD-L1 interaction for cancer immunotherapy
This publication cites Anti-PD-L1 Aptamer [N5] (Biotin) (A321196).
Article Abstract

Threose nucleic acid (TNA) aptamers were selected in vitro to bind PD-L1 protein and inhibit its interaction with PD-1. These biologically stable TNA aptamers bound target proteins with nanomolar affinities, and effectively blocked PD-1/PD-L1 interaction in vitro. After injection into a colon cancer xenograft mouse model, the TNA aptamer N5 was specifically accumulated at the tumour site, and significantly inhibited tumour growth in vivo.

View Publication
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