Anti-Cardiac Troponin I Antibody [596] (A278793)

Anti-Cardiac Troponin I Antibody [596]

Mouse monoclonal [596] antibody to Cardiac Troponin I.

This antibody recognises human cardiac Troponin I (cTnI). Troponin I is a 24kDa subunit of Troponin, a protein found on muscle tissue responsible for muscle contraction. When calcium binds to Troponin C, a conformational change moves Troponin I and tropomyosin out of the way of the myosin binding sites on the actin filaments in muscles. This allows cross-bridging to occur and the muscle to contract. Levels of cTnI in serum are commonly used as a marker for cardiac cell damage and death. recognises an epitope between amino acid residues 169 - 178 and does not cross react with skeletal TnI.

WB, ELISA, IP

Human

Mixture of free human cardiac Troponin I and native human cardiac Troponin complex.

Mouse

Monoclonal

596

IgG1

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human Troponin I (Cardiac) antibody, clone 596 recognizes human cardiac Troponin I (cTnI). Troponin I is a 24kDa subunit of Troponin, a protein found on muscle tissue responsible for muscle contraction. When calcium binds to Troponin C, a conformational change moves Troponin I and tropomyosin out of the way of the myosin binding sites on the actin filaments in muscles. This allows cross-bridging to occur and the muscle to contract. Levels of cTnI in serum are commonly used as a marker for cardiac cell damage and death. Mouse anti Human Troponin I (Cardiac) antibody, clone 596 recognizes an epitope between amino acid residues 169 - 178 and does not cross react with skeletal TnI.

TNNC1, TNNI3, Troponin I, cardiac muscle