This antibody recognises calretinin, a ~29 kDa calcium binding protein found mostly in the central nervous system and retina. It is a cytoplasmic protein involved in the regulation of calcium concentration, which is important in the regulation of a large variety of neuronal functions, including neurotransmitter release, ionic channel permeability, enzyme activity, and gene transcription. Mice deficient in calretinin show impairment in motor coordination.Calretinin is a sensitive and specific marker for mast cells.
Applications
WB, IHC-Fr
Dilutions
IHC-Fr: 1:500, WB: 1:1,000
Reactivity
Guinea Pig, Rat, Human, Mouse, Primate
Immunogen
Purified guinea pig calretinin.
Host
Sheep
Clonality
Polyclonal
Isotype
IgG
Conjugate
Unconjugated
Concentration
Lot Specific
Molecular Weight
Approximately 29 kDa in rat cerebellum.
Product Form
Liquid
Formulation
Supplied in TRIS Buffered Saline.
Storage
Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.
General Notes
Sheep anti calretinin antibody recognizes calretinin, a ~29 kDa calcium binding protein found mostly in the central nervous system and retina. It is a cytoplasmic protein involved in the regulation of calcium concentration, which is important in the regulation of a large variety of neuronal functions, including neurotransmitter release, ionic channel permeability, enzyme activity, and gene transcription. Mice deficient in calretinin show impairment in motor coordination.Calretinin is a sensitive and specific marker for mast cells.