Anti-C6 Antibody [056B-214.2.4.2] (A278907)

Anti-C6 Antibody [056B-214.2.4.2]

Mouse monoclonal [056B-214.2.4.2] antibody to C6.

This antibody recognises complement component 6 (C6), a 104 kDa member of the complement C6/C7/C8/C9 family present in blood serum. The factor I modules of C6 bind the C-terminus of the C5b alpha-chain, anchoring the molecule to the membrane; they also binds complement component 7. This enables the formation of the C5b–7 precursor complex. C5b–7 then functions as a receptor for components C8 and C9 which form the complement membrane attack complex (MAC). Deficiency of C6 results in susceptibility to bacterial infection.recognises C6 as a component of the MAC.

Flow Cytometry, ELISA, IHC-Fr

Human

Purified human C6.

Mouse

Monoclonal

056B-214.2.4.2

IgG1

Unconjugated

1 mg/ml

Liquid

Supplied in Borate Buffered Saline with 0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human C6 antibody, clone 056B-214.2.4.2 recognises complement component 6 (C6), a 104 kDa member of the complement C6/C7/C8/C9 family present in blood serum. The factor I modules of C6 bind the C-terminus of the C5b alpha-chain, anchoring the molecule to the membrane; they also binds complement component 7. This enables the formation of the C5b–7 precursor complex. C5b–7 then functions as a receptor for components C8 and C9 which form the complement membrane attack complex (MAC). Deficiency of C6 results in susceptibility to bacterial infection.Mouse anti Human C6 antibody, clone 056B-214.2.4.2 recognises C6 as a component of the MAC.

AW111623, CO6_HUMAN, Complement component 6, Complement component C6