Anti-C4d Antibody [057-51.5.1.6] (A278910)

Anti-C4d Antibody [057-51.5.1.6]

Mouse monoclonal [057-51.5.1.6] antibody to C4d.

This antibody recognises a neoantigen on the secreted protein complement component 4d (C4d). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b’s alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. This requires C4 binding protein or CR1 as a cofactor. iC4b is further degraded into C4d and C4c. The short half life of C4d means that it is present in serum at high enough concentrations to make it a useful marker for classical complement activation.C4 has been linked to susceptibility to systemic lupus erythematosous.

ELISA, IHC-Fr

Human

Purified human C4d.

Mouse

Monoclonal

057-51.5.1.6

IgG1

Unconjugated

Protein A affinity chromatography of ascites.

Lot Specific

Supplied in Borate Buffered Saline with 0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human C4d (Neoantigen) antibody, clone 057-51.5.1.6 recognizes a neoantigen on the secreted protein complement component 4d (C4d). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b’s alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. This requires C4 binding protein or CR1 as a cofactor. iC4b is further degraded into C4d and C4c. The short half life of C4d means that it is present in serum at high enough concentrations to make it a useful marker for classical complement activation.C4 has been linked to susceptibility to systemic lupus erythematosous.

acidic C4, Acidic complement C4, basic C4, basic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3, C4, C4, chido form, C4, Rodgers form, C4-1, C4A, C4a anaphylatoxin, C4A2, C4A3, C4A4, C4A6, C4AD, C4b, C4B1, C4B12, C4B2, C4B3, C4B5, C4BD, C4B_2, C4d fragment, C4F, C4S, CH, Chido form of C4, CO4, CO4A_HUMAN, Complement C4 gamma chain, complement C4-A, complement C4-B, complement C4-B-like, complement C4B1a, Complement component 4A, complement component 4A (Rodgers blood group), Complement component 4B, complement component 4B (Chido blood group), complement component 4B (Chido blood group), copy 2, complement component 4B (Chido blood group)-like, Complement component 4F, Complement component 4S, CPAMD2, CPAMD3, DADB-112B14.11, MGC164979, RG, Rodgers form of C4