Recombinant Anti-beta III Spectrin Antibody [rSPTBN2/1778] (A250043)

Recombinant mouse monoclonal [rSPTBN2/1778] antibody to beta III Spectrin for ELISA and WB.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-beta III Spectrin Antibody [rSPTBN2/1778]
Description
Recombinant mouse monoclonal [rSPTBN2/1778] antibody to beta III Spectrin .
Specificity
Spectrin is an actin binding protein that is a major component of the plasma membrane skeleton. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Vertebrate spectrins have two alpha-subunits (alpha-I/alpha-II) four beta-subunits (beta-I-beta-IV) and a beta-H subunit creating diversity and specialization of function. Spectrin and spectrin are present in erythrocytes, whereas spectrin II (also designated fodrin ) and spectrin I (also designated fodrin ) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Spectrin III is highly homologous to both spectrin I and spectrin II. Spectrin III is highly expressed in brain, kidney, pancreas and liver, and at lower levels in lung and placenta. Spectrin beta 3 is primarily expressed in nervous tissues with highest expression levels in the cerebellum, where it is found in Purkinje cell soma and dendrites.
Applications
ELISA, WB
Dilutions
WB: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment, around amino acids 356-475, of human SPTBN2 protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
rSPTBN2/1778
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
246 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-beta III Spectrin Antibody [rSPTBN2/1778] - BSA and Azide free (A253223).
Synonyms
Glutamate transporter EAAT4 associated protein 41, GTRAP41, SCA 5, SCA5, SCAR14, Spectrin beta chain brain 2, Spectrin beta III sigma 2, Spectrin beta non erythrocytic 2, Spectrin non erythroid beta chain 2, Spinocerebellar ataxia 5, Spinocerebellar ataxia 5 protein, SPTBN 2, SPTBN2
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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