Anti-beta III Spectrin Antibody [RG/26] (A250042)

Anti-beta III Spectrin Antibody [RG/26]

Mouse monoclonal [RG/26] antibody to beta III Spectrin .

Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane of many cell types in pentagonal or hexagonal arrangements, forming a scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure. In certain types of brain injury such as diffuse axonal injury, spectrin is irreversibly cleaved by the proteolytic enzyme calpain, destroying the cytosketelon. Spectrin cleavage causes the membrane to form blebs and ultimately to be degraded, usually leading to cell death.

ELISA, WB, IF, IHC-P

WB: 1-2 µg/ml, IF: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human, Mouse, Rat

Red cell membranes.

Mouse

Monoclonal

RG/26

IgG2a

kappa

Protein A/G chromatography.

200 µg/ml

246 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-beta III Spectrin Antibody [RG/26] - BSA and Azide free (A253222).