Anti-beta 2 Microglobulin Antibody [B2M/961] - BSA and Azide free
Description
Mouse monoclonal [B2M/961] antibody to beta 2 Microglobulin.
Specificity
This antibody recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
B2M, B2MG_HUMAN, Beta 2 microglobin, Beta 2 microglobulin precursor , Beta chain of mhc class 1 proteins , Beta chain of MHC class I molecules, Beta-2-microglobulin form pI 5.3, CDABP0092, Hdcma22p, IMD43
SDS-PAGE analysis of Anti-beta 2 Microglobulin Antibody [B2M/961] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.
Immunofluorescent analysis of HeLa cells stained with Anti-beta 2 Microglobulin Antibody [B2M/961] followed by Goat Anti-Mouse IgG (CF® 488) (Green). The nuclear counterstain is RedDot (Red).
Flow cytometric analysis of human HeLa cells using Anti-beta 2 Microglobulin Antibody [B2M/961] followed by Goat Anti-Mouse IgG (CF® 488) (Blue). Isotype Control (Red).
Publishing research using Anti-beta 2 Microglobulin Antibody [B2M/961] - BSA and Azide free (A252932)? Please let us know so that we can list the citation on this page.
Alternative products to Anti-beta 2 Microglobulin Antibody [B2M/961] - BSA and Azide free (A252932)