Anti-BCOR Antibody [BCOR/2372] (A314502)

$765

Mouse monoclonal [BCOR/2372] antibody to BCOR for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-BCOR Antibody [BCOR/2372]
Description
Mouse monoclonal [BCOR/2372] antibody to BCOR.
Specificity
Bcl-6, a transcriptional repressor, can promote or inhibit apoptosis depending on the cell type and also plays an important role in normal immune responses. Bcl-6 negatively regulates NFB-mediated cellular functions and is frequently found to be deregulated in non-Hodgkin s lymphoma. BCoR (Bcl-6 corepressor) is a 1,755 amino acid protein that associates with histone deacetylases (HDACs) to transcriptionally repress Bcl-6. With ubiquitous expression, BCoR is localized to the nucleus where it interacts with other proteins through its three ANK repeat domains. Mutations in the gene encoding BCoR result in microphthalmia with associated anomalies 2, also known as anophthalmia, which is characterized by variable features, such as renal aplasia, mental retardation, hyospadias, microencephaly and cryptorchidism. There are four isoforms of BCoR which are produced as a result of alternative splicing events.
Applications
IHC-P
Positive Control
Ubiquitously expression.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment (around Amino Acids 100-400) of human BCOR protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
BCOR/2372
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
192 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
5830466J11Rik, 8430401K06Rik, ANOP 2, ANOP2, BCL 6 co repressor, BCL 6 corepressor, BCL 6 interacting corepressor, BCL-6 corepressor, BCL6 co repressor, BCL6 corepressor, BCL6 interacting corepressor, BCOR_HUMAN, FLJ20285, FLJ38041, KIAA1575, MAA 2, MAA2, MCOPS 2, MCOPS2, MGC131961, MGC71031
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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