Anti-BCMA Antibody [CD269/8508R] - BSA and Azide free
Description
Recombinant rabbit monoclonal [CD269/8508R] antibody to BCMA.
Specificity
The B cell maturation protein (BCMA) is a type I integral membrane protein that belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is expressed as a 184 amino acid peptide that is expressed only in mature B-lymphocytes and is located on the cis part of the Golgi apparatus. BCMA shares significant homology with TACI (transmembrane activator) within the cysteine-rich domain. TACI has been shown to bind CAML, which induces activation of NFAT (nuclear factor of activated T cells). Both BCMA and TACI have been shown to bind APRIL and TALL-1, which stimulate B cell proliferation in conjunction with other B-cell activators. When overexpressed, TALL-1 stimulates the development of systemic lupus erythaematosus (SLE).
Applications
ELISA, IHC-P
Positive Control
NAMALWA cells. Tonsil or gastric carcinoma (IHC).
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant human CD269 protein fragment (around Amino Acids 1-184). The exact sequence is proprietary.
Host
Rabbit
Clonality
Monoclonal
Clone ID
CD269/8508R
Isotype
IgG
Light Chains
kappa
Conjugate
Unconjugated
Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
20 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
B cell maturation antigen, B cell maturation factor, B cell maturation protein, B-cell maturation protein, BCM, CD269, CD269 antigen, TNFRSF17, TNR17_HUMAN, Tumor necrosis factor receptor superfamily member 17
This product is for research use only. It is not intended for diagnostic or therapeutic use.
Publishing research using Recombinant Anti-BCMA Antibody [CD269/8508R] - BSA and Azide free (A315880)? Please let us know so that we can list the citation on this page.
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