Recombinant Anti-Bcl6 Antibody [BCL6/8983R] (A314492)

Anti-Bcl6 Antibody [BCL6/8983R]

Recombinant rabbit monoclonal [BCL6/8983R] antibody to Bcl6.

Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ( LH ) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.

Raji or Ramos cells. Human tonsil or Hodgkin s lymphoma.

IHC: 1-2 µg/ml

Human

Recombinant fragment (aa1-400) of human BCL6 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

BCL6/8983R

IgG

Unconjugated

Protein A/G chromatography.

200 µg/ml

95 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

B cell CLL/lymphoma 6, B cell lymphoma 6 protein, B-cell lymphoma 5 protein, B-cell lymphoma 6 protein, BCL 5, Bcl 6, BCL-5, BCL-6, BCL5, BCL6A, BCL6_HUMAN, cys his2 zinc finger transcription factor, LAZ 3, LAZ 3 protein, LAZ3, Lymphoma associated zinc finger gene on chromosome 3, Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3), Protein LAZ-3, ZBTB 27, ZBTB27, Zinc finger and BTB domain containing protein 27, Zinc finger and BTB domain-containing protein 27, Zinc finger and BTB domain-containing protein 27 (ZBTB27), Zinc finger protein 51, Zinc Finger Protein 51 (ZNF51), zinc finger transcription factor BCL6S, ZNF 51, ZNF51