Recombinant Anti-Bcl-6 Antibody [rBCL6/1475] - BSA and Azide free (A253082)

Name: Anti-Bcl-6 Antibody [rBCL6/1475] - BSA and Azide free
Brand: Antibodies.com
SKU: A253082
Price: 525.0 USD
Availability: InStock

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$525

Recombinant mouse monoclonal [rBCL6/1475] antibody to Bcl-6 for WB.

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Alternative Formats and ConjugatesAlternative Formats

Unconjugated

Delivery

Freight Charges

$40 to United States

Lead Time

4-6 Business Days

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Recombinant Antibody

Specifications

Name

Anti-Bcl-6 Antibody [rBCL6/1475] - BSA and Azide free

Description

Recombinant mouse monoclonal [rBCL6/1475] antibody to Bcl-6.

Specificity

The specificity of this monoclonal antibody to its intended target was validated by HuProt^TM Array, containing more than 19,000 full-length human proteins. Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ('LH') cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.

Applications

Dilutions

WB: 1-2 µg/ml

Reactivity

Human

Immunogen

Recombinant fragment, around amino acids 256-389, of human Bcl-6 protein. The exact sequence is proprietary.

Host

Mouse

Clonality

Monoclonal

Clone ID

rBCL6/1475

Isotype

IgG1

Light Chains

kappa

Conjugate

Unconjugated

Purification

Protein A/G chromatography.

Concentration

1 mg/ml

Molecular Weight

95 kDa

Product Form

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Notes

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-Bcl-6 Antibody [rBCL6/1475] (A249902).

Synonyms

B Cell Lymphoma 6 Protein, B-cell CLL/lymphoma 6, B-cell lymphoma 5 protein, B-cell lymphoma 6 protein transcript, BCL5, BCL6A, cys-his2 zinc finger transcription factor, LAZ3, lymphoma-associated zinc finger gene on chromosome 3, Protein LAZ-3, ZBTB27, Zinc finger and BTB domain-containing protein 27, Zinc Finger Protein 51, zinc finger transcription factor BCL6S, ZNF51

Isotype Controls

Suitable Secondaries

See all Anti-Mouse IgG Secondaries →

Disclaimer

This product is for research use only. It is not intended for diagnostic or therapeutic use.

Scientific Validation Data (1)

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Figure 1: SDS-PAGE - Anti-Bcl-6 Antibody [rBCL6/1475] - BSA and Azide free (A253082)

SDS-PAGE analysis of Anti-Bcl-6 Antibody [rBCL6/1475] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.

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