Recombinant Anti-Bcl-6 Antibody [rBCL6/1475] (A249902)

Anti-Bcl-6 Antibody [rBCL6/1475]

Recombinant mouse monoclonal [rBCL6/1475] antibody to Bcl-6.

The specificity of this monoclonal antibody to its intended target was validated by HuProt^TM Array, containing more than 19,000 full-length human proteins. Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ('LH') cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.

WB: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 256-389, of human Bcl-6 protein. The exact sequence is proprietary.

Mouse

Monoclonal

rBCL6/1475

IgG1

Protein A/G chromatography.

200 µg/ml

95 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Bcl-6 Antibody [rBCL6/1475] - BSA and Azide free (A253082).

B-cell lymphoma 5 protein, B-cell lymphoma 6 protein, BCL-5, BCL5, LAZ3, Protein LAZ-3, ZBTB27, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51, ZNF51