Anti-Aurora B Antibody [AURKB/1592] (A250523)

Name: Anti-Aurora B Antibody [AURKB/1592]
Brand: Antibodies.com
SKU: A250523
Price: 525.0 USD
Availability: InStock

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$525

Mouse monoclonal [AURKB/1592] antibody to Aurora B for IHC-P.

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Delivery

Freight Charges

$40 to United States

Lead Time

4-6 Business Days

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Specifications

Name

Anti-Aurora B Antibody [AURKB/1592]

Description

Mouse monoclonal [AURKB/1592] antibody to Aurora B.

Specificity

This antibody recognizes a protein of 39kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.

Applications

IHC-P

Dilutions

IHC-P: 1-2 µg/ml

Reactivity

Human

Immunogen

Recombinant fragment, around amino acids 89-251, of human Aurora B protein. The exact sequence is proprietary.

Host

Mouse

Clonality

Monoclonal

Clone ID

AURKB/1592

Isotype

IgG1

Light Chains

kappa

Conjugate

Unconjugated

Purification

Protein A/G chromatography.

Concentration

200 µg/ml

Molecular Weight

39 kDa

Product Form

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Notes

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Aurora B Antibody [AURKB/1592] - BSA and Azide free (A253703).

Synonyms

AIK2, AIM-1, AIM1, ARK-2, ARK2, AurB, AURKB, AURKB_HUMAN, Aurora 1, Aurora and Ipl1 like midbody associated protein 1, Aurora kinase B, Aurora related kinase 2, Aurora- and Ipl1-like midbody-associated protein 1, Aurora-B, Aurora-related kinase 2, Aurora/IPL1 related kinase 2, Aurora/IPL1-related kinase 2, IPL1, PPP1R48, Protein phosphatase 1 regulatory subunit 48, Serine/theronine kinase 12, Serine/threonine protein kinase 12, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase aurora-B, STK-1, STK1, STK12, STK5

Isotype Controls

Suitable Secondaries

See all Anti-Mouse IgG Secondaries →

Disclaimer

This product is for research use only. It is not intended for diagnostic or therapeutic use.

Scientific Validation Data (3)

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Figure 1: Immunohistochemistry - Anti-Aurora B Antibody [AURKB/1592] (A250523)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon using Anti-Aurora B Antibody [AURKB/1592].

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Figure 2: Immunohistochemistry - Anti-Aurora B Antibody [AURKB/1592] (A250523)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human prostate carcinoma using Anti-Aurora B Antibody [AURKB/1592].

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Figure 3: SDS-PAGE - Anti-Aurora B Antibody [AURKB/1592] (A250523)

SDS-PAGE analysis of Anti-Aurora B Antibody [AURKB/1592] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.

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