Recombinant Anti-ATRX Antibody [ATRX/7188R] (A314481)

Anti-ATRX Antibody [ATRX/7188R]

Recombinant rabbit monoclonal [ATRX/7188R] antibody to ATRX.

ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, ATRX predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 thalassemia or ATRX syndrome

Raji, HeLa or A431 cells. Human pancreas, adrenal, ovary, kidney, prostate or stomach.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 2200-2450) of human ATRX protein. The exact sequence is proprietary.

Rabbit

Monoclonal

ATRX/7188R

IgG

Unconjugated

Protein A/G chromatography.

200 µg/ml

280 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Alpha thalassemia/mental retardation syndrome X linked homolog, ATP dependent helicase ATRX, ATP-dependent helicase ATRX, ATR2, ATRX_HUMAN, DNA dependent ATPase and helicase, Helicase 2, X linked, MGC2094, MRXHF1, RAD54, RAD54L, SFM1, SHS, Transcriptional regulator ATRX, X linked helicase II, X linked nuclear protein, X-linked helicase II, X-linked nuclear protein, XH2, XNP, Znf HX, Znf-HX