Anti-alpha 1 Antichymotrypsin Antibody [SERPINA3/4189] (A277558)

Mouse monoclonal [SERPINA3/4189] antibody to alpha 1 Antichymotrypsin for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 5-8 business days.
Name
Anti-alpha 1 Antichymotrypsin Antibody [SERPINA3/4189]
Description
Mouse monoclonal [SERPINA3/4189] antibody to alpha 1 Antichymotrypsin.
Specificity
It recognizes a protein of 65-76kDa, which is identified antichymotrypsin (AACT). AACT is a plasma protease inhibitor synthesized in the liver as a single glycopeptide chain. In human, the normal serum level of AACT is about one-tenth that of α 1-antitrypsin (AAT), with which it shares nucleic acid and protein sequence homology. Both are major acute phase reactants; their concentrations in plasma increase in response to trauma, surgery and infection. Elevated levels of AACT are widely, but not universally, reported in the cerebrospinal fluid and plasma of AD patients. Prostate-specific antigen (PSA) and its SDS-stable complex with AACT are in widespread use as markers for the diagnosis of prostate cancer. AACT deficiency may also be a possible cause of chronic liver disease. AACT antibody reacts with histiocytes and histiocytic neoplasms. It is widely used to identify histiocytes and tumors derived from them. Acinar tumors of the pancreas and salivary gland may also exhibit AACT positivity.
Applications
IHC-P
Dilutions
IHC-P: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment, around amino acids 49-187, of human alpha 1 Antichymotrypsin. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
SERPINA3/4189
Isotype
IgG2a
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
65-76 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-alpha 1 Antichymotrypsin Antibody [SERPINA3/4189] - BSA and Azide free (A278146).
Synonyms
AACT, ACT, Alpha-1-antichymotrypsin, Cell growth-inhibiting gene 24/25 protein, Serpin A3, SERPINA3
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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