Recombinant Anti-ACTH Antibody [rCLIP4278] (A277910)

Anti-ACTH Antibody [rCLIP4278]

Recombinant mouse monoclonal [rCLIP4278] antibody to ACTH.

ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to CLIP (aa25-39 of ACTH); does not react with Synacthen (aa1-24 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.

IHC-P: 1-2 µg/ml

Human

Synthetic peptide corresponding to amino acids 1-24 of human ACTH.

Mouse

Monoclonal

rCLIP4278

IgG2a

Protein A/G chromatography.

200 µg/ml

ACTH is ~5 kDa / the POMC precursor is ~30 kDa.

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-ACTH Antibody [rCLIP4278] - BSA and Azide free (A278498).

Corticotropin-lipotropin, Pro-opiomelanocortin