Anti-TLR9 Antibody (A282966)

Anti-TLR9 Antibody

Goat polyclonal antibody to TLR9.

This antibody recognises an epitope within the N-terminal region of CD289, a member of the toll-like receptor family, which triggers MyD88 and TRAF6, resulting in NF-kappaB activation, cytokine secretion and the inflammatory response. CD289 acts as a receptor for unmethylated cytidine-phosphate-guanosine dinucleotides in bacterial DNA (CpG-DNA), playing a primary role in pathogen recognition and activation of innate immunity and has been shown to play a role in defence against systemic mouse cytomegalovirus infection. Goat anti Mouse CD289 antibody is reported as suitable for use in immunocytochemistry on acetone fixed cells.

WB, IHC-P

IHC-P: 1:125, WB: 1:500

Mouse, Human

Synthetic peptide sequence LSLKYNNLTKVPRQLPPSLEY-C corresponding to amino acids 204-224 within the N-terminus of mouse CD289.

LSLKYNNLTKVPRQLPPSLEY-C

Goat

Polyclonal

IgG

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.1% BSA and <0.1% Sodium Azide.

Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Goat anti Mouse CD289 antibody recognises murine Toll-like receptor 9, also known as CD289 or TLR9. CD289 is an 1032 amino acid ~120 kDa endosomal single pass type I transmembrane glycoprotein with a number of leucine rich repeats and a single TIR domain (UniProt: Q9NR96). Goat anti Mouse CD289 antibody recognizes an epitope within the N-terminal (NT) region of CD289, a member of the toll-like receptor family, which triggers MyD88 and TRAF6, resulting in NF-kappaB activation, cytokine secretion and the inflammatory response. CD289 acts as a receptor for unmethylated cytidine-phosphate-guanosine dinucleotides in bacterial DNA (CpG-DNA), playing a primary role in pathogen recognition and activation of innate immunity and has been shown to play a role in defence against systemic mouse cytomegalovirus infection. Goat anti Mouse CD289 antibody is reported as suitable for use in immunocytochemistry on acetone fixed cells.

CD289, Toll-like receptor 9