This antibody recognises the C-terminal (CT) region of T-cell immunoglobulin mucin-4 (TIM-4), also known as SMUCKLER. TIM-4 is a ~ 42 kDa type I membrane protein which is preferentially expressed on macrophages and dendritic cells. TIM-4 is the ligand of TIM-1, and binding leads to T-cell proliferation and cytokine production. Polymorphisms in the TIM-4 gene may be associated with a predisposition to asthma.
Applications
WB
Dilutions
WB: 1.0 - 2 µg/ml
Reactivity
Human, Rat, Mouse
Immunogen
A peptide corresponding to 15 amino acids near the C-terminus of human TIM-4.
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Conjugate
Unconjugated
Concentration
1 mg/ml
Molecular Weight
Approximately 54 kDa in Jurkat cell lysate.
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Rabbit anti Human TIM-4 antibody recognizes the C-terminal (CT) region of T-cell immunoglobulin mucin-4 (TIM-4), also known as SMUCKLER. TIM-4 is a ~ 42 kDa type I membrane protein which is preferentially expressed on macrophages and dendritic cells. TIM-4 is the ligand of TIM-1, and binding leads to T-cell proliferation and cytokine production. Polymorphisms in the TIM-4 gene may be associated with a predisposition to asthma.
Synonyms
T-cell immunoglobulin and mucin domain-containing protein 4, T-cell immunoglobulin mucin receptor 4, T-cell membrane protein 4, TIM-4, TIM4, TIMD-4, TIMD4
