Recombinant Anti-CD22 Antibody [rBLCAM/6749] (A277934)

Anti-CD22 Antibody [rBLCAM/6749]

Recombinant mouse monoclonal [rBLCAM/6749] antibody to CD22.

This antibody recognizes a protein of 130-140kDa, identified as CD22 (also known as BL-CAM). CD22 expression is restricted to normal and neoplastic B cells and is absent from other haemopoietic cell types. In B-cell ontogeny, CD22 is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. It is not expressed by plasma cells, CD22 is found highly expressed in follicular mantle and marginal zone B-cells, and while germinal center B-cells are relatively weak. CD22 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation.

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 52-178, of human CD22 protein. The exact sequence is proprietary.

Mouse

Monoclonal

rBLCAM/6749

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

130-140 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-CD22 Antibody [rBLCAM/6749] - BSA and Azide free (A278522).

B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, Sialic acid-binding Ig-like lectin 2, Siglec-2, SIGLEC2, T-cell surface antigen Leu-14